Baseball has been a part of the Simpsons storylines on several occasions.
1990-Nov-08: Dancin' Homer - season 2 episode 5 - Homer tells his bar buddies the story of how his drunken antics at a baseball game with his boss landed him a job as a dancing mascot for the Springfield Isotopes
1992-Feb-20: Homer at the Bat – season 3 episode 17 - The Springfield Nuclear Power Plant's softball team is surprisingly successful thanks to Homer, but Mr. Burns decides to call in Major League Baseball ringers for the championship game anyway especially after making a $1 million dollar bet that his team will win. Features – Don Mattingly, Wade Boggs, Roger Clemens, Ken Griffey, Jr., Steve Sax, Ozzie Smith, José Canseco, Darryl Strawberry, Mike Scioscia
2025-Apr-27: Abe League of Their Moe – season 36 episode 15 - After Grampa and Moe recruit a Macedonian slugger to play in Springfield, it strains their friendship and the very integrity of baseball. The episode features guest stars Kevin Burkhardt, Steve Gelbs, Kevin Millar